Lin28-let-7a antagonist 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.

Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.(In Vitro):When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM.?Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency.?Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA.?

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Others

Other Targets

PEGs

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2024548-03-4

583.6

C31H29N5O7

>98% (HPLC)

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CC1(C)Oc2cc(N3CCN(CC3)C(=O)OCc3ccccc3)c(cc2-c2c1cnn2-c1ccc(cc1)C(O)=O)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years